82:T824,

For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market? An Introduction to Medicinal Chemistry, sixth edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part one of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups.The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development. The Online Resource Centre features: For students: * Multiple Choice Questions to support self-directed learning * Web articles describing recent developments in the field and further information on topics covered in the book * Journal Club to encourage students to critically analyse the research literature * Molecular Modelling Exercises, with new exercises in Chem3D * New assignments to help students develop data analysis and problem solving skills For registered adopters of the book: * A test bank of additional multiple-choice questions, with links to relevant sections in the book * Answers to end-of-chapter questions. * Figures from the book, ready to download. * Power Point slides to accompany every chapter in the book.

83:T587,Medication is widely used to support the human body to fight against infection and pain. In an era of pharmaceutical and medicinal challenges, we have all become more familiar with drug production and distribution. However, do we really know what happens before those drugs are distributed? What's the process behind drug discovery? How do our bodies interact with those chemicals?
An Introduction to Medicinal Chemistry, 7th edition, offers a complete and accessible approach to this multidisciplinary field. Its student-friendly writing style makes this text an ideal tool for those coming to the subject for first time, but also for students looking to deepen their understanding.
The book guides students through understanding the principles of drug action targets in Part A, to how drugs interact at a molecular level with our organs to offer therapeutic value in Part B, and exploring drug design and discovery, as well as regulatory procedures in Part C. Offering a practical approach, Part D provides a deeper look at specific tools and techniques of medicinal chemistry, concluding with emerging topics including antibodies and anticancer agents in Part E.
From principles to practice, accompanied by examples and case studies emerging from current biomedical research, the book will equip students with a robust understanding of medicinal chemistry, to prepare them for future success.84:T691,An Introduction to Medicinal Chemistry is the leading text for university courses on this subject. Renowned for being a textbook loved equally by both students and lecturers, it presents complete coverage in an accessible and engaging style. The text begins with the essential biochemistry on which an understanding of medicinal chemistry is built, introducing the structure and function of important drug targets. It then explores how drugs interact with the body and the consequences of those reactions. There is a section on general principles and strategies involved in discovering and designing new drugs, and another on useful 'tools of the trade'. The text ends with a contemporary look at specific topics within medicinal chemistry, for example, antiviral and anticancer agents; cholinergics and anticholinesterases; and antiulcer agents. Learning features throughout An Introduction to Medicinal Chemistry help to unlock this fascinating subject. A glossary helps to familiarise the language of medicinal chemistry. Boxes present in-depth material and explore how concepts are applied in practice. Key points summarise sections within chapters, providing a basis for revision, and questions at the end of chapters and on the accompanying Online Resource Centre allow the reader to test their understanding and develop molecular modelling skills. Online Resource Centre The Online Resource Centre features: For registered adopters of the book: · Answers to end-of-chapter questions · Figures from the book · Power Point slides · Test Bank questions For students: · Multiple Choice Questions · Web articles · Molecular Modelling Exercises · 3D Rotatable structures85:T744,

The average person in the UK will take more than 14,000 pills over the course of their life, yet few people consider the long road of development that has made that drug work without being toxic. An Introduction to Medicinal Chemistry presents the field in an engaging style that is very accessible to students. Medicinal chemistry is a fast-moving field whose continuous new developments have far-reaching implications for world health. As such, this text presents a complete course in medicinal chemistry, from first principles of drug action, to design and development, to specific drugs from HIV inhibitors to painkillers. The book builds on the history of drug development, but does not assume much background knowledge. The focus is on building upon the understandings of the molecular function of drugs, and from there, taking a broad overview of the topical issues and most frequently used techniques. An Introduction to Medicinal Chemistry remains a leading text for the growing number of medicinal chemistry courses internationally, especially as modules in medical chemistry become a more popular option on chemistry courses.With enhanced attention to the pedagogical details such as key points and boxes, as well as having specific case studies highlighted in distinct sections, Patrick's new edition enables a full understanding of the subject and a clear idea of where the field is heading.Online Resource Centre The Online Resource Centre features: For registered adoptors of the book: * Answers to end-of-chapter questions * Figures from the book * Power Point slides * Test Bank questions For students: * Hyperlinked bibliography * Six-monthly updates to text * 3D Rotatable structures

86:T7dd,Many of us think nothing of taking a painkiller to ease a headache, or to relieve the symptoms of 'flu. But how do drugs have their effect in the human body? How are new drugs discovered and designed to be as effective as possible? An Introduction to Medicinal Chemistry offers an engaging insight into the one field of chemistry that arguably has the greatest impact on our quality of life than any other. Newly structured into four parts, the book opens in Part A with an introduction to pharmacodynamics and pharmacokinetics. Pharmacodynamics considers the types of molecular targets used by drugs, the interactions which are involved when a drug meets that target, and the consequences of those interactions. Pharmacokinetics considers the issues involved in a drug reaching its target in the first place. Part B goes on to examine the general principles and strategies involved in discovering and designing new drugs and developing them for the marketplace, while Part C looks at particular 'tools of the trade' which are invaluable in those processes. Finally, Part D covers a selection of specific topics within medicinal chemistry. Reflecting a change in emphasis in medicinal chemistry research, this Part takes us from the largely trial-and-error approach to drug design to the rational approach, and explores the most recent advances in molecular biology and genetics which have revolutionised drug design. With a striking new two-colour text design, and greatly enriched learning features, the third edition conveys the fascination of working in a field which overlaps the disciplines of chemistry, biochemistry, physiology, microbiology, cell biology, and pharmacology. A must-have textbook for any student of medicinal chemistry. Companion Web Site - Figures available to download, to facilitate lecture preparation - 3D molecular structures, to enable students to visualise key structures in an interactive way - Multiple choice questions with answers, to support and encourage independent learning3c:["$","$L7d",null,{"state":{"mutations":[],"queries":[{"dehydratedAt":1793422855854,"state":{"data":{"pages":[{"requestId":"a891c46b-98e8-4ba6-8b86-0791b4486f40","total":{"value":8,"relation":"eq"},"rows":[{"entityType":"book","isbn":"9780198749691","id":496931,"score":2,"position":0,"book":{"id":496931,"isbn":"9780198749691","created":"2021-06-17T17:07:53.000Z","title":"An introduction to medicinal chemistry","description":"$82","htmlDescription":null,"pages":912,"language":"eng","depth":30,"height":190,"width":264,"weight":1702,"edition":"6","publishDate":"2017","authorNames":"Graham L. 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Instant Notes in Medicinal Chemistry provides concise coverage for undergraduates studying medicinal chemistry as part of a science, pharmacy or medical course. It is a truly multidisciplinary subject involving such subject specialities as organic chemistry, pharmacology, biochemistry, physiology, microbiology, toxicology, genetics and computer modeling. It concentrates on the fundamental principles of medicinal chemistry and assumes no more than elementary background of chemistry or biology. (Bookdata)

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