Molecular toxicology

Molecular Toxicology reflects the revolution that toxicology has undergone in the last decade, as the molecular and genetic basis of the science--including drug metabolism, carcinogenesis, programmed cell death, and DNA repair--has been elucidated. It is the first text to explain the principles of toxicology in depth and from the perspective of modern biochemistry and molecular biology, while also providing a sense of the historical development of the science. Emphasizing the latest molecular biological approaches, the book covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosamines, polycyclic aromatic hydrocarbons, and chlorinated compounds. The toxicology of oxygen and oxidative stress is also covered in depth. Extensively referenced, up-to-date, and rigorous, Molecular Toxicology is an ideal textbook for advanced undergraduate and graduate courses in molecular and biochemical toxicology, and also serves as a valuable resource for instructors and practicing scientists.